Hydrogen Bromide → HCID 86613285, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(1H-indol-2-yl)-3-(methylthio)imidazo[1,5-a]pyrazin-8-amine (250 mg, 0.85 mmol) in AcOH (10 mL) was treated with 48% hydrogen bromide (0.6 mL) and the mixture heated 120° C. for 24 h. The reaction mixture was then cooled and the suspended solid isolated by filtration and washed with hexane to afford 240 mg of 8-amino-1-(1H-indol-2-yl)imidazo[1,5-a]pyrazine-3(2H)-thione hydrobromide. 1H NMR (400 MHz, MeOD) δ ppm 6.89 (d, J=6.06 Hz, 1H), 7.03 (s, 1H), 7.17 (tt, J=7.07, 0.76 Hz, 1H), 7.31 (tt, J=7.33, 1.01 Hz, 1H), 7.52 (dd, J=0.76 Hz, 1H), 7.63-7.76 (m, 2H); MS (ES+): m/z 282.07 [MH+].

Provenance & Evidence