Hydrochloric Acid → HCID 16753773, compound

Participants

Reaction Steps

A solution of [8-amino-1-(1H-indol-2-yl)-imidazo[1,5-a]pyrazin-3-ylsulfanyl]-acetic acid ethyl ester (6.7 mg, 0.000018 mol) and conc. HCl (3.0 mL) was stirred at rt for 5 h. The conc. HCl was removed in vacuo to afford 6 mg, 90% yield, of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6) δ ppm =4.12 (s, 2H), 6.82 (s, 1H), 7.07 (t, J=7.83, 7.07 Hz, 11H), 7.14-7.22 (m, 2H), 7.48 (d, J=8.08 Hz, 11H), 7.63 (d, J=7.83 Hz, 11H), 7.71 (d, J=5.56 Hz, 1H) and 11.75 (s, 1H); MS (ES+): m/z 339.92 [M+]. HPLC: tR=1.94 min (OpenLynx: polar—5 min).

Provenance & Evidence