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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1992454Generated: October 25, 2026

1-(1-Piperidinylsulfonyl)piperazine → [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(piperidine-1-sulfonyl)-piperazin-1-yl]-methanone

https://huagongshe.com/reaction/1992454

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(1-Piperidinylsulfonyl)piperazineHCID 285501—
Reactant[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanoneHCID 68538245—
Product[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-[4-(piperidine-1-sulfonyl)-piperazin-1-yl]-methanoneHCID 6853651687%

Reaction Steps

The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b), and 1-(piperidin-1-yl-sulfonyl)-piperazine to afford the desired product as a light-brown solid (87%). MS (ISP): 531.2 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07648979B2
Source datasetuspto-grants-2010_01
ORD IDord-4876ddd2906248b899240877ec34e2ae
Source noteuspto-grants-2010_01