HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethyl-methanesulfonate → [5-(4-Isopropyl-piperazine-1-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethyl-methanesulfonate | HCID 21470016 | — |
| Reactant | [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone | HCID 68538245 | — |
| Product | [5-(4-Isopropyl-piperazine-1-carbonyl)-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone | HCID 68535572 | 54% |
Reaction Steps
The title compound was synthesized in analogy to example 3, from [5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone (example 1) and 2,2,2-trifluoroethyl-methanesulfonate to afford the desired product as a colorless foam (54%). MS (ISP): 544.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07648979B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-ad07b4929a8d47caa8308eb42818acf8 |
| Source note | uspto-grants-2010_01 |