HCID 53445148, compound → (4-Cyclopropanecarbonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone

HRID 1992475Notes

Reaction equation

HRID 1992475 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26](S(C)(=O)=O)[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].Cl.N1(C(N)=O)CCNCC1.[CH:43]1([C:46]([OH:48])=O)[CH2:45][CH2:44]1>>[CH:43]1([C:46]([N:26]2[CH2:27][CH2:28][N:23]([C:21]([C:16]3[NH:17][C:18]4[C:14]([CH:15]=3)=[CH:13][C:12]([C:10]([N:7]3[CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:9][CH2:8]3)=[O:11])=[CH:20][CH:19]=4)=[O:22])[CH2:24][CH2:25]2)=[O:48])[CH2:45][CH2:44]1

Participants

3

Reactant 2

HCID 53445148HCID 53445148, compoundHCID 68538245[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone2×

Product 1

HCID 68538998(4-Cyclopropanecarbonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanoneYield 89%

Procedure

The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b), and cyclopropylcarboxylic acid 1-piperazineamide hydrochloride to afford the desired product as a light-brown foam (89%). MS (ISP): 452.2 (M+H)+.

Sources & evidence

ORD record
ord-0ec2e8fa48f94eb8abdc70975eb7e41e
Source dataset
uspto-grants-2010_01
Patent number
US07648979B2

Reaction notes

Loading…