HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-1-(piperazin-1-yl)propan-1-one → 1-{4-[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indole-2-carbonyl]-piperazin-1-yl}-2-methyl-propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-1-(piperazin-1-yl)propan-1-one | HCID 2761409 | — |
| Reactant | [5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone | HCID 68538245 | — |
| Product | 1-{4-[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indole-2-carbonyl]-piperazin-1-yl}-2-methyl-propan-1-one | HCID 68533986 | 91% |
Reaction Steps
The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and 1-(2-methylpropanoyl)-piperazine to afford the desired product as light-brown foam (91%). MS (ISP): 454.3 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07648979B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-d20a8de6f4fa45f28374a5d1039efdce |
| Source note | uspto-grants-2010_01 |