Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1992482Generated: October 25, 2026

1-(Cyclopropylsulfonyl)piperazine → (4-Cyclopropanesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanone

https://huagongshe.com/reaction/1992482

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Cyclopropylsulfonyl)piperazineHCID 45496790—
Reactant[5-(4-Isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanoneHCID 68538245—
Product(4-Cyclopropanesulfonyl-piperazin-1-yl)-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indol-2-yl]-methanoneHCID 6853567993%

Reaction Steps

The title compound was synthesized in analogy to example 1, from 5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carboxylic acid hydrochloride (example 1, intermediate b) and cyclopropylsulfonyl-piperazine to afford the desired product as light brown foam (93%). MS (ISP): 488.1 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07648979B2
Source datasetuspto-grants-2010_01
ORD IDord-cfd5e82d764e4117835dfabed1358419
Source noteuspto-grants-2010_01