HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-N-methyl-acetamide → [1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-N-methyl-acetamide | HCID 58955136 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | [1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-methyl-amine | HCID 58955138 | 278.2% |
Reaction Steps
N-[1-(6-Methoxy-[1,5]naphthyridin-4-yl)-pyrrolidin-3-yl]-N-methyl-acetamide (500 mg, 1.67 mmol) was suspended in 3N HCl (aq) and refluxed overnight. The solution was evaporated to dryness and azeotroped with acetonitrile to provide the title compound (1.2 g, 85%) as a white solid: LC-MS mlz 259 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07648984B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-c0e7ecad2c1949659529665b8506f0ad |
| Source note | uspto-grants-2010_01 |