Potassium Carbonate → HCID 58955132, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl {1-[6-(methyloxy)-1,5-naphthyridin-4-yl]-3-pyrrolidinyl}{2-[(trifluoroacetyl)amino]ethyl}carbamate (1.8 g, 3.65 mmol) in MeOH/H2O (75 mL, 2:1) was added K2CO3 (2.52 g, 18.25 mmol). After 12 h at 25° C., the reaction was concentrated under reduced pressure and purified via column chromatography [silica, 5% MeOH in DCM (2% NH4OH)] affording the title compound (1.24 g, 88%) as an off-white solid: LC/MS (ES) m/e 388 (M+H)+.

Provenance & Evidence