HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionyl chloride → HCID 67144739, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionyl chloride | HCID 62324 | — |
| Reactant | 4-hydroxy-5-Methyl-5-octylthiophen-2(5H)-one | HCID 135538018 | — |
| Product | HCID 67144739 | HCID 67144739 | 48.1% |
Reaction Steps
From 32 (40 mg, 0.17 mmol) and propionyl chloride (20 μL, 0.22 mmol) following general procedure K was obtained 64 (23.1 mg, 47%) after flash chromatography (15% EtOAc/Hexanes). 1H NMR (300 MHz, CDCl3) δ 0.85 (t, J=7 Hz, 3H), 1.12-1.25 (m, 13H), 1.42-1.49 (m, 2H), 1.64 (s, 3H), 1.78-1.84 (m, 2H), 2.57 (q, J=7.5 Hz, 2H), 6.39 (s, 1H); 13C NMR (75 MHz, CDCl3) δ 8.71, 14.0, 22.6, 25.1, 25.9, 27.9, 29.1, 29.3, 29.5, 31.8, 38.6, 60.4, 113.8, 169.1, 177.0, 179.9. IR (NaCl) 2928, 1787, 1688 cm−1; Analysis Calculated for C16H26O3S: C, 64.4; H, 8.78; Found: C, 64.3; H, 8.89.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649012B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-fcfafa5a2a0741e3a7e826695cf80633 |
| Source note | uspto-grants-2010_01 |