反应详情

Butyryl chloride (4.7 mL, 45.4 mmol) was added dropwise to a solution of 3-[(3-amino[1,5]naphthyridin-4-yl)amino]propyl acetate prepared in Part C in dichloromethane (160 mL) at 0° C. The solution was allowed to warm to room 3 temperature and stir for 1 hour, then was concentrated under reduced pressure to provide 3-{[3-(butyrylamino)[1,5]naphthyridin-4-yl]amino}propyl acetate hydrochloride as a dark orange foam that was used directly in the next step.

1. temperatureto warm to room 3 temperature
2. concentrationwas concentrated under reduced pressure