Hydrazine → HCID 68539852, compound

HRID 1992622Notes

Reaction equation

HRID 1992622 reaction equation
[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:31][O:32][CH2:33][CH3:34])[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][O:19][N:20]3C(=O)C4C(=CC=CC=4)C3=O)[C:10]=2[C:9]2[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=2[N:3]=1.NN>>[NH2:20][O:19][CH2:18][CH2:17][CH2:16][CH2:15][N:14]1[C:10]2[C:9]3[CH2:8][CH2:7][CH2:6][CH2:5][C:4]=3[N:3]=[C:2]([NH2:1])[C:11]=2[N:12]=[C:13]1[CH2:31][O:32][CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 9321HydrazineHCID 68537709HCID 68537709, compound

Product 1

HCID 68539852HCID 68539852, compound

Procedure

The method described in Part C of Example 140 can be used to treat 2-{4-[4-amino-2-(ethoxymethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-1-yl)butoxy]-1H-isoindole-1,3(2H)-dione with anhydrous hydrazine to provide 1-[4-(aminooxy)butyl]-2-(ethoxymethyl)-6,7,8,9-tetrahydro-1H-imidazo[4,5-c]quinolin-4-amine.

Sources & evidence

ORD record
ord-e2f9eee1f8584663838d2bf7bcb14e9c
Source dataset
uspto-grants-2010_01
Patent number
US07648997B2

Reaction notes

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