Ammonium Hydroxide → 2-[5-(4-Methyl-piperazin-1-yl)-2-nitro-pyridin-3-yl]-acetamide

Participants

Reaction Steps

A solution of [5-(4-Methyl-piperazin-1-yl)-2-nitro-pyridin-3-yl]-acetic acid methyl ester (222 mg, 0.75 mmol) in 33% aq. NH4OH (100 mL) is stirred for 16 h at 50° C. in a sealed autoclave. TLC analysis indicated complete consumption of starting material. The solvent is evaporated at reduced pressure to afford the title compound as a yellow solid in a 3:2 mixture with the corresponding carboxylic acid. 1H NMR (d6-DMSO 400 MHz): δ 2.18 (s, 3H), 2.36-2.44 (m, 4H), 3.36-3.44 (m, 4H), 3.77 (s, 2H), 6.92 (bs, 1H), 7.34 (d, J=2 Hz, 1H), 7.44 (bs, 1H), 8.07 (d, J=2 Hz, 1H). ES+−MS: 280.4 [M+H]+.

Provenance & Evidence