HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2,4-Dichloro-5-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,4-Dichloro-5-(chloromethyl)pyridine | HCID 2762728 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2,4-Dichloro-5-methylpyridine | HCID 12643718 | — |
Reaction Steps
2,4-Dichloro-5-chloromethyl-pyridine (1.43 g, 7.28 mmol) is dissolved in ethanol (14 ml). After addition of triethyl amine (737 mg, 7.28 mmol), Raney nickel (143 mg) is added. The reaction vessel is connected to a balloon filled with H2. After 3 hours of very vigorous magnetically stirring at RT, NMR analysis of a reaction aliquot indicated complete conversion of the starting material. The reaction mixture is diluted with EtOAc and poured into water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07648989B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-79a391b269bb465b85cdd312f2bedf29 |
| Source note | uspto-grants-2010_01 |