Methyl(3S,4R)-1-benzyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate → methyl (3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate

Participants

Reaction Steps

Palladium hydroxide (20% on carbon, 1 g) was added to a solution of methyl (3S,4R)-1-benzyl-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate, from preparation 30 (10 g, 30 mmol) in ethanol (50 mL) at room temperature. The reaction mixture was hydrogenated at 50 psi for 24 hours and then filtered through Arbocel® washing with ethanol (50 mL). The solvent was removed in vacuo to give the desired compound as a colourless oil, 7.19 g (98%).

Provenance & Evidence