1-((1-Methyl-4-piperidinyl)methyl)piperazine → HCID 11502362, compound

HRID 1992695Notes

Reaction equation

HRID 1992695 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH2:4][CH2:3]1.[C:15]1([CH:21]([N:28]=[C:29]=[O:30])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[CH:21]([NH:28][C:29]([N:12]1[CH2:13][CH2:14][N:9]([CH2:8][CH:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)[CH2:10][CH2:11]1)=[O:30])([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 27369421-((1-Methyl-4-piperidinyl)methyl)piperazineHCID 4250935(Isocyanatomethylene)dibenzene

Product 1

HCID 11502362HCID 11502362, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 1-(1-methyl-piperidin-4-ylmethyl)-piperazine (0.5 g, 2.7 mmol) in dry CH2Cl2 (12 ml) was added diphenylmethyl isocyanate (0.56 ml, 2.7 mmol) drop wise under nitrogen. The resulting mixture was stirred at room temperature over night. Removal of solvent under reduced pressure followed by column chromatography using CH2Cl2: CH3OH (10:1) gives the desired product in 82% yield.

Workup

  1. customRemoval of solvent under reduced pressure

Sources & evidence

ORD record
ord-57a67a1767a141e9b98b8a9c4391d6f1
Source dataset
uspto-grants-2010_01
Patent number
US07649092B2

Reaction notes

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