反应详情

To a solution of 4-chlorophenyl 1-methylpiperidin-4-yl methanone 1.19 g (5 mmol) in 30 ml methanol was added in small portions sodium borohydride 0.378 g (10 mmol). The reaction mixture was stirred at room temperature for two hours, concentrated, added water and extracted with methylene chloride 2×50 ml. The combined organic solution was dried over sodium sulfate and concentrated to give 1.2 g of desired product in 98% yield.

1. concentrationconcentrated
2. additionadded water
3. extractionextracted with methylene chloride 2×50 ml
4. dry with materialThe combined organic solution was dried over sodium sulfate
5. concentrationconcentrated