HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 59716934, compound → HCID 51664402, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 59716934 | HCID 59716934 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 51664402 | HCID 51664402 | 50% |
Reaction Steps
To a solution of (S)-1-benzyl-4-[(1-methylpiperidin-2-yl)methyl]piperazine 0.87 g (3.03 mmol) in THF (40 ml) was added 10% Pd/C 0.4 g and exposed to 1 atm hydrogen overnight. The reaction mixture was filtered. The filtrate was concentrated 0.3 g of desired product in 50% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07649092B2 |
| Source dataset | uspto-grants-2010_01 |
| ORD ID | ord-5a7867ddbbf7407f9767ec4bf7602e41 |
| Source note | uspto-grants-2010_01 |