Acetic Acid → HCID 72524905, compound

Participants

Reaction Steps

Experimental condition analogous to Example 14 were used with 7-methoxy-2,2-dimethyl-benzo[1,3]dioxole-5-carboxylic acid (4-hydroxy-pyrrolidin-2-ylmethyl)-(2-methyl-3-phenyl-allyl)-amide 0.16 g (0.35 mmol), tetrahydro-4H-pyrane-4-one 0.042 g (0.42 mmol), acetic acid 0.03 ml (0.53 mmol) and sodium cyanoborohydride 0.026 g (0. 42 mmol). After transforming the free base to HCl salt, 130 mg of white solid was obtained. Yield: 65%.

Provenance & Evidence