Sodium Hydroxide → HCID 86614808, compound

Participants

Reaction Steps

To a solution of the intermediate from step A (0.1 g, 0.18 mmol) in 10 ml of THF/MeOH was added 5 N NaOH (1 mL). After stirring the reaction at room temperature for 2 hours it was concentrated in vacuo. The residue was acidified with 1N HCl (10 ml) and was extracted with ethyl acetate, dried over anhydrous Na2SO4 filtered and concentrated in vacuo. This material was used in the next step without any further purification. 1H NMR (CD3OD, 500 MHz): 7.96 (d, J=8.2 Hz, 2H), 7.73 (d, J=8.9 Hz, 2H), 7.62 (t, J=7.1 Hz, 2H), 7.4 (s, 1H), 7.35 (d, J=8.2 Hz, 2H), 7.27 (d, J=8.7 Hz, 2H), 5.88 (s, 2H). LC-MS=4.0 min; (M+H)=536.0.

Provenance & Evidence