1,2-Dichloroethane → HCID 86761041, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the intermediate from step D (0.1 g, 0.41 mmol) in DMF (2 mL) was added 4-trifluoromethoxy aniline (83 μL, 0.61 mmol), DIEA (215 μL, 1.23 mmol), HOAt (0.08 g, 0.61 mmol) and EDC (0.118 g, 0.61 mmol). The reaction was heated at 50° C. for 3 hours. The reaction was diluted with ethyl acetate, washed with 1N HCl , saturated NaHCO3, and saturated NaCl solutions. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash chromatography using 30% ethyl acetate hexanes. 1H NMR (DMSO, 500 MHz): 10.34 (bs, 1H), 7.93 (d, J=5.9 Hz, 2H), 7.8 (bm, 2H), 7.44 (bs, 1H), 7.37 (bd, J=8.0 Hz, 2H). LC-MS=3.76 min; (M+H)=402.

Provenance & Evidence