Acetic Acid → HCID 6910008, compound

Participants

Reaction Steps

To a solution of 4-carbomethoxy benzaldehyde (5.0 g, 36.46 mmol) in dichloroethane (40 mL) was added tert-butyl carbazate (4.03 g, 30.46 mmol) followed by AcOH (1.74 mL, 30.46 mmol). After 1.5 hours, the reaction was concentrated in vacuo. The residue was dissolved in ethyl acetate, washed with saturated NaHCO3, solution, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. This material was used without any further purification in the next step. 1H NMR (CDCl3, 500 MHz): 8.03 (d, J=8.5 Hz, 3H), 7.93 (bs, 1H), 7.8 (d, J=8.2 Hz, 2H), 3.96 (s, 3H), 1.58 (s, 9H). LC-MS=3.1; (M+H−56)=223.1.

Provenance & Evidence