Hydrochloric Acid → HCID 68536320, compound

Participants

Reaction Steps

Compound 25 (130 mg, 0.29 mmol, 1 equiv) was dissolved in EtOH (5 mL) and THF (5 mL). A solution of 1 N NaOH (2.9 mL, 2.85 mmol, 10 equiv)) was added and the solution refluxed for 1.5 h. The reaction was cooled to RT and then acidified to pH 2 with 1 N HCl. The product was extracted with EtOAc (100 mL) and the organic layer was washed with saturated aqueous NaCl (50 mL), dried over Na2SO4, filtered and concentrated to provide the title compound (26) (204 mg, 100%), as a pale yellow solid. 1HNMR (400 MHz, DMSO-d6): δ 7.74 (s, 1H), 7.58 (m, 2), 7.38 (m, 2H), 7.32-7.16 (m, 6H), 7.11 (m, 1H), 6.36 (m, 2H), 3.87 (s, 3H), 2.18 (s, 3H). LRMS m/z 429.4 (M+H)+.

Provenance & Evidence