Hydrochloric Acid → HCID 68539548, compound

Participants

Reaction Steps

As described for Example 2 (Step 5), treatment of 3-Methyl-6-(methyloxy)-1-{[(methyloxy)methyl]oxy}-2-[4-(methyloxy)phenyl]naphthalene (44) (0.41 g, 1.21 mmol) with 4 M HCl in dioxane at room temperature yielded 0.30 g (89%) of the title compound (45) as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 2.16 (s, 3H), 3.88 (s, 3H), 3.92 (s, 3H), 5.23 (s, 1H), 7.02-7.10 (m, 4H), 7.20 (s, 1H), 7.26 (d, J=8.6 Hz, 2H), 8.07 (d, J=9.2 Hz, 1H). LCMS (APCI): m/z 295 (M+H)+, m/z 291 (M−H)−.

Provenance & Evidence