Sodium hydride → HCID 86616644, compound

Participants

Reaction Steps

3-Methyl-6-(methyloxy)-2-[4-(methyloxy)phenyl]-1-naphthalenol (45) (0.30 g, 1.00 mmol) was treated with NaH in DMF followed by addition of 4-fluorobenzaldehyde to give 0.32 g (81%) of the title compound (46) as a light yellow foam. 1H NMR (400 MHz, CDCl3): δ 2.26 (s, 3H), 3.76 (s, 3H), 3.93 (s, 3H), 6.71 (d, J=8.8 Hz, 2H), 6.79 (d, J=8.7 Hz, 2H), 7.02-7.07 (m, 3H), 7.14 (d, J=2.6 Hz, 1H), 7.58 (s, 1H), 7.63 (d, J=8.8 Hz, 2H), 7.66 (d, J=9.1 Hz, 1H), 9.80 (s, 1H). LCMS (APCI): m/z 399 (M+H)+.

Provenance & Evidence