Sodium Hydroxide → HCID 68537308, compound

Participants

Reaction Steps

Ethyl ester 74 (0.45 g, 0.97 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.33 g (78%) of the title compound (75) as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 1.19 (d, J=6.8 Hz, 6H), 2.90 (sept, J=6.8 Hz, 1H), 3.94 (s, 3H), 6.22 (d, J=15.9 Hz, 1H), 6.56 (d, J=8.8 Hz, 2H), 7.04 (dd, J1=9.1 Hz, J2=2.4 Hz, 1H), 7.06-7.15 (m, 2H), 7.18-7.30 (m, 6H), 7.62 (d, J=16.0 Hz, 1H), 7.65 (s, 1H), 7.69 (d, J=9.1 Hz, 1H). LCMS (ESI): m/z 439 (M+H)+.

Provenance & Evidence