Sodium Hydroxide → HCID 68536111, compound

Participants

Reaction Steps

Ethyl ester 83 (0.30 g, 0.62 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.24 g (86%) of the title compound (84) as a white solid. 1H NMR (400 MHz, CDCl3): δ 0.77 (t, J=7.3 Hz, 3H), 1.10-1.28 (m, 2H), 1.40-1.50 (m, 2H), 2.50-2.60 (m, 2H), 3.93 (s, 3H), 6.22 (d, J=16.0 Hz, 1H), 6.58 (d, J=8.6 Hz, 2H), 7.04 (dd, J1=9.1 Hz, J2=2.4 Hz, 1H), 7.08-7.15 (m, 2H), 7.16 (d, J=2.4 Hz, 1H), 7.18-7.30 (m, 5H), 7.58 (s, 1H), 7.62 (d, J=15.9 Hz, 1H), 7.69 (d, J=9.2 Hz, 1H). LCMS (ESI): m/z 453 (M+H)+, m/z 451 (M−H)−.

Provenance & Evidence