Sodium Hydroxide → HCID 11516447, compound

Participants

Reaction Steps

Ethyl ester 88 (123 mg, 0.30 mmol) was saponified with 1 N NaOH in THF and EtOH to give 90 mg (79%) of the title compound (89) as a white solid. mp 224-225° C. 1H NMR (400 MHz, CDCl3): δ 2.26 (s, 3H), 6.22 (d, J=16.0 Hz, 1H), 6.61 (d, J=8.8 Hz, 2H), 7.10-7.16 (m, 2H), 7.20-7.30 (m, 5H), 7.38 (t, J=7.4 Hz, 1H), 7.49 (t, J=7.2 Hz, 1H), 7.62 (d, J=15.9 Hz, 1H), 7.68 (s, 1H), 7.80 (d, J=8.5 Hz, 1H), 7.84 (d, J=8.3 Hz, 1H). LCMS (ESI): m/z 381 (M+H)+, m/z 379 (M−H)−. Anal. Calc for C26H20O3.0.33H2O: C, 80.81; H, 5.39. Found: C, 80.73; H, 5.03.

Provenance & Evidence