Oxalyl chloride → HCID 68537219, compound

Participants

Reaction Steps

3-{[3-(Methyloxy)phenyl]methyl}hexanoic acid (92) (2.76 g, 11.7 mmol) was treated with oxalyl chloride followed by AlCl3 in CH2Cl2 to give 2.10 g (82%) of compound 93 as a light yellow solid. 1H NMR (400 MHz, CDCl3): δ 0.90-1.00 (m, 3H), 1.35-1.50 (m, 4H), 2.10-2.35 (m, 2H), 2.60-2.75 (m, 2H), 2.90-3.00 (m, 1H), 3.85 (s, 3H), 6.65-6.70 (m, 1H), 6.82 (dd, J1=8.7 Hz, J2=1.4 Hz, 1H), 7.98 (d, J=8.8 Hz, 1H). LCMS (ESI): m/z 219 (M+H)+.

Provenance & Evidence