Sodium Hydroxide → HCID 68537313, compound

Participants

Reaction Steps

Ethyl ester (107) (0.82 g, 1.70 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.77 g (˜100%) of the title compound (108) as an off-white foam. 1H NMR (400 MHz, CDCl3): δ 0.75 (d, J=6.4 Hz, 6H), 1.60-1.70 (m, 1H), 2.46 (d, J=7.1 Hz, 2H), 3.93 (s, 3H), 6.22 (d, J=15.9 Hz, 1H), 6.57 (d, J=8.6 Hz, 2H), 7.04 (dd, J1=9.2 Hz, J2=2.2 Hz, 1H), 7.06-7.14 (m, 2H), 7.16 (d, J=2.2 Hz, 1H), 7.18-7.25 (m, 5H), 7.54 (s, 1H), 7.63 (d, J=16.0 Hz, 1H), 7.70 (d, J=9.2 Hz, 1H). LCMS (ESI): m/z 453 (M+H)+, m/z 451 (M−H)−.

Provenance & Evidence