Sodium hydride → HCID 86616656, compound

Participants

Reaction Steps

6-(Methyloxy)-2-phenyl-3-(3,3,3-trifluoropropyl)-1-naphthalenol (125) (0.35 g, 1.00 mmol) was treated with NaH in DMF followed by addition of 4-fluorobenzaldehyde to give 0.32 g (71%) of the title compound (126) as a light yellow viscous oil. 1H NMR (400 MHz, CDCl3): δ 2.10-2.25 (m, 2H), 2.80-2.90 (m, 2H), 3.94 (s, 3H), 6.67 (d, J=8.8 Hz, 2H), 7.07-7.14 (m, 3H), 7.18 (d, J=2.4 Hz, 1H), 7.22-7.30 (m, 3H), 7.60-7.64 (m, 3H), 7.70 (d, J=9.2 Hz, 1H), 9.80 (s, 1H). LCMS (ESI): m/z 451 (M+H)+.

Provenance & Evidence