Oxalyl chloride → HCID 68534728, compound

Participants

Reaction Steps

3-{[4-Fluoro-3-(methyloxy)phenyl]methyl}hexanoic acid (132) (1.92 g, 7.55 mmol) was treated with oxalyl chloride followed by AlCl3 in CH2Cl2 to give 1.70 g (95%) of the title compound (133) as a white solid. 1H NMR (400 MHz, CDCl3): δ 0.90-0.95 (m, 3H), 1.35-1.45 (m, 4H), 2.10-2.30 (m, 2H), 2.60-2.75 (m, 2H), 2.90-3.00 (m, 1H), 3.93 (s, 3H), 6.74 (d, J=7.7 Hz, 1H), 7.70 (d, J=11.5 Hz, 1H). LCMS (ESI): m/z 236 (M+H)+.

Provenance & Evidence