Chloromethyl Methyl Ether → HCID 68537292, compound

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Reaction Steps

2-Bromo-7-fluoro-6-(methyloxy)-3-propyl-1-naphthalenol (134) (0.52 g, 1.66 mmol) was treated with chloromethyl methyl ether in the presence of diisopropylethylamine in THF to give 0.49 g (83%) of the title compound (135) as a light yellow oil. 1H NMR (400 MHz, CDCl3): δ 1.01 (t, J=7.3 Hz, 3H), 1.65-1.75 (m, 2H), 2.83 (t, J=7.8 Hz, 2H), 3.72 (s, 3H), 3.98 (s, 3H), 5.21 (s, 2H), 7.10 (d, J=8.3 Hz, 1H), 7.37 (s, 1H), 7.76 (d, J=12.4 Hz, 1H). LCMS (ESI): m/z 379 (M+Na)+.

Provenance & Evidence