Sodium Hydroxide → HCID 68536417, compound

Participants

Reaction Steps

Ethyl ester (139) (0.44 g, 0.91 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.33 g (80%) of the title compound (140) as a white solid. 1H NMR (400 MHz, CDCl3): δ 0.80 (t, J=7.3 Hz, 3H), 1.40-1.55 (m, 2H), 2.52 (t, J=7.8 Hz, 2H), 4.01 (s, 3H), 6.23 (d, J=15.9 Hz, 1H), 6.55 (d, J=8.8 Hz, 2H), 7.06-7.12 (m, 2H), 7.20-7.30 (m, 6H), 7.41 (d, J=12.1 Hz, 1H), 7.56 (s, 1H), 7.62 (d, J=15.9 Hz, 1H). LCMS (APCI): m/z 457 (M+H)+, m/z 455 (M−H)−.

Provenance & Evidence