Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 86087083, compound

Participants

Reaction Steps

Treatment of methyl 2-[3-(methyloxy)-1-propyn-1-yl]benzoate (142) (0.64 g, 3.13 mmol) with a mixture of N,O-dimethylhydroxylamine hydrochloride and nBuLi gave 0.35 g (48%) of the title compound (143) as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 3.32 (br s, 3H), 3.43 (s, 3H), 3.50 (br s, 3H), 4.30 (s, 2H), 7.25-7.40 (m, 3H), 7.45-7.55 (m, 1H). LCMS (ESI): m/z 234 (M+H)+.

Provenance & Evidence