Cesium carbonate → HCID 86087089, compound

Participants

Reaction Steps

3-[(Methyloxy)methyl]-2-phenyl-1-naphthalenol (145) (46 mg, 0.17 mmol) and 4-fluorobenzaldehyde was heated with Cs2CO3 in DMF at 100° C. to give 20 mg (30%) of the title compound (146) as a light yellow viscous oil. 1H NMR (400 MHz, CDCl3): δ 3.34 (s, 3H), 4.32 (s, 2H), 6.71 (d, J=8.8 Hz, 2H), 7.16-7.20 (m, 2H), 7.20-7.30 (m, 3H), 7.45 (t, J=7.5 Hz, 1H), 7.54 (t, J=7.4 Hz, 1H), 7.62 (d, J=8.6 Hz, 2H), 7.81 (d, J=8.4 Hz, 1H), 7.95 (d, J=9.0 Hz, 1H), 7.98 (s, 1H), 9.79 (s, 1H). LCMS (APCI): m/z 369 (M+H)+.

Provenance & Evidence