HCID 86087094, compound → HCID 68534812, compound

Participants

Reaction Steps

2-(Cyclopropylethynyl)-N-methyl-N,4-bis(methyloxy)benzamide (150) (0.47 g, 1.82 mmol) was treated with benzylmagnesium chloride in THF to give 0.47 g (89%) of the title compound (151) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 0.80-0.95 (m, 4H), 1.45-1.55 (m, 1H), 3.82 (s, 3H), 4.41 (s, 2H), 6.80 (dd, J1=8.8 Hz, J2=2.6 Hz, 1H), 6.94 (d, J=2.5 Hz, 1H), 7.20-7.26 (m, 3H), 7.27-7.33 (m, 2H), 7.65 (d, J=8.8 Hz, 1H). LCMS (ESI): m/z 291 (M+H)+.

Provenance & Evidence