Potassium bis(trimethylsilyl)amide → HCID 68539304, compound

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A solution of 1-[2-(Cyclopropylethynyl)-4-(methyloxy)phenyl]-2-phenylethanone (151) (0.47 g, 1.62 mmol) in toluene was treated with a KHMDS solution in toluene to give 0.18 g (38%) of the title compound (152) as a light yellow viscous oil. 1H NMR (400 MHz, CDCl3): δ 0.70-0.80 (m, 4H), 1.55-1.65 (m, 1H), 3.91 (s, 3H), 5.22 (s, 1H), 6.92 (s, 1H), 7.00-7.10 (m, 2H), 7.40-7.48 (m, 3H), 7.50-7.57 (m, 2H), 8.07 (d, J=8.9 Hz, 1H). LCMS (APCI): m/z 291 (M+H)+, m/z 289 (M−H)+.

Provenance & Evidence