Sodium Hydroxide → HCID 68539395, compound

Participants

Reaction Steps

Ethyl ester (154) (0.21 g, 0.45 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.19 g (96%) of the title compound (155) as a white solid. 1H NMR (400 MHz, CDCl3): δ 0.75-0.85 (m, 4H), 1.60-1.70 (m, 1H), 3.92 (s, 3H), 6.22 (d, J=15.9 Hz, 1H), 6.60 (d, J=8.6 Hz, 2H), 7.02 (dd, J1=9.2 Hz, J2=2.4 Hz, 1H), 7.13 (d, J=2.2 Hz, 1H), 7.18-7.30 (m, 8H), 7.62 (d, J=15.9 Hz, 1H), 7.68 (d, J=8.9 Hz, 1H). LCMS (APCI): m/z 437 (M+H)+, m/z 435 (M−H)−.

Provenance & Evidence