Cesium carbonate → 4-({3-Butyl-2-[4-(methyloxy)phenyl]-1-naphthalenyl}oxy)benzaldehyde

関与物質

反応手順

3-Butyl-2-[4-(methyloxy)phenyl]-1-naphthalenol (160) (0.25 g, 0.82 mmol) and 4-fluorobenzaldehyde was heated with Cs2CO3 in DMSO at 100° C. to give 0.23 g (69%) of compound 161 as a light brown viscous oil. 1H NMR (400 MHz, CDCl3): δ 0.80 (t, J=7.3 Hz, 3H), 1.20-1.30 (m, 2H), 1.40-1.50 (m, 2H), 2.60 (t, J=7.8 Hz, 2H), 3.78 (s, 3H), 6.71 (d, J=8.8 Hz, 2H), 6.79 (d, J=8.6 Hz, 2H), 7.05 (d, J=8.7 Hz, 2H), 7.39 (t, J=7.4 Hz, 1H), 7.50 (t, J=7.5 Hz, 1H), 7.64 (d, J=8.8 Hz, 2H), 7.70 (s, 1H), 7.77 (d, J=8.2 Hz, 1H), 7.87 (d, J=8.1 Hz, 1H), 9.81 (s, 1H). LCMS (ESI): m/z 411 (M+H)+.

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