Sodium Hydroxide → HCID 44580027, compound

Participants

Reaction Steps

Ethyl ester (162) (0.25 g, 0.52 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.21 g (88%) of compound 163 as a white solid. mp 186-187° C. 1H NMR (400 MHz, CH3OH-d4): δ 0.78 (t, J=7.3 Hz, 3H), 1.15-1.29 (m, 2H), 1.40-1.50 (m, 2H), 2.62 (t, J=7.3 Hz, 2H), 3.75 (s, 3H), 6.26 (d, J=15.9 Hz, 1H), 6.56 (d, J=8.8 Hz, 2H), 6.83 (d, J=8.6 Hz, 2H), 7.07 (d, J=8.6 Hz, 2H), 7.30-7.40 (m, 3H), 7.47 (t, J=7.5 Hz, 1H), 7.53 (d, J=16.0 Hz, 1H), 7.50-7.56 (m, 2H), 7.89 (d, J=8.2 Hz, 1H). LCMS (ESI): m/z 453 (M+H)+, m/z 451 (M−H)−.

Provenance & Evidence