Sodium Hydroxide → HCID 44580026, compound

Participants

Reaction Steps

Ethyl ester (168) (0.25 g, 0.53 mmol) was saponified with 1 N NaOH in THF and EtOH to give 0.18 g (79%) of the title compound (169) as a white solid. mp 169-170° C. 1H NMR (400 MHz, CH3OH-d4): δ 0.78 (t, J=7.3 Hz, 3H), 1.15-1.28 (m, 2H), 1.40-1.50 (m, 2H), 2.60 (t, J=7.9 Hz, 2H), 6.27 (d, J=16.0 Hz, 1H), 6.56 (d, J=8.6 Hz, 2H), 7.01 (t, J=8.7 Hz, 2H), 7.12-7.22 (m, 2H), 7.32-7.42 (m, 3H), 7.46-7.56 (m, 2H), 7.70-7.80 (m, 2H), 7.90 (d, J=8.2 Hz, 1H). LCMS (ESI): m/z 441 (M+H)+, m/z 439 (M−H)−. Anal. Calc for C29H25FO3.0.1H2O: C, 78.75; H, 5.74. Found: C, 78.85; H, 5.64.

Provenance & Evidence