Cesium carbonate → 4-[(3-Butyl-2-phenyl-1-naphthalenyl)oxy]benzaldehyde

Participants

Reaction Steps

3-Butyl-2-phenyl-1-naphthalenol (172) (0.30 g, 1.09 mmol) and 4-fluorobenzaldehyde was heated with Cs2CO3 in DMSO at 100° C. to give 0.28 g (67%) of the title compound (173) as a light yellow viscous oil. 1H NMR (400 MHz, CDCl3): δ 0.77 (t, J=7.3 Hz, 3H), 1.15-1.30 (m, 2H), 1.40-1.55 (m, 2H), 2.58 (t, J=7.8 Hz, 2H), 6.68 (d, J=8.6 Hz, 2H), 7.08-7.14 (m, 2H), 7.19-7.26 (m, 3H), 7.39 (t, J=7.4 Hz, 1H), 7.50 (1, J=7.3 Hz, 1H), 7.62 (d, J=8.8 Hz, 2H), 7.71 (s, 1H), 7.77 (d, J=8.4 Hz, 1H), 7.88 (d, J=8.3 Hz, 1H), 9.79 (s, 1H). LCMS (APCI): m/z 381 (M+H)+.

Provenance & Evidence