HCID 58597415, compound → HCID 68536721, compound

Participants

Reaction Steps

Ethyl (2E)-4,4,4-trifluoro-3-(phenylmethyl)-2-butenoate (175-E) (0.85 g, 3.30 mmol) was hydrogenated at room temperature with 10% Pd/C under a hydrogen balloon to yield 0.77 g (90%) of the title compound (176) as a colorless oil. From ethyl (2Z)-4,4,4-trifluoro-3-(phenylmethyl)-2-butenoate (175-Z) (0.35 g, 1.36 mmol), 0.31 g (88%) of the title compound (176) was obtained as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 1.18 (t, J=7.2 Hz, 3H), 2.35 (dd, J1=16.4 Hz, J2=6.3 Hz, 1H), 2.55 (dd, J1=16.5 Hz, J2=6.2 Hz, 1H), 2.60-2.70 (m, 1H), 3.00-3.15 (m, 2H), 4.00 (q, J=7.2 Hz, 2H), 7.15-7.25 (m, 3H), 7.26-7.35 (m, 2H).

Provenance & Evidence