Cesium carbonate → HCID 86087146, compound

Participants

Reaction Steps

2-Phenyl-3-(trifluoromethyl)-1-naphthalenol (182) (0.19 g, 0.66 mmol) and 4-fluorobenzaldehyde was heated with Cs2CO3 in DMSO at 100° C. to give 92 mg (36%) of the title compound (183) as alight brown solid. 1H NMR (400 MHz, CDCl3): δ 6.67 (d, J=8.8 Hz, 2H), 7.14 (d, J=6.9 Hz, 2H), 7.18-7.27 (m, 3H), 7.58-7.70 (m, 4H), 7.89 (d, J=8.2 Hz, 1H), 8.05 (d, J=8.1 Hz, 1H), 8.27 (s, 1H), 9.82 (s, 1H). LCMS (ESI): m/z 415 (M+Na)+.

Provenance & Evidence