Hydrochloric Acid → HCID 68536227, compound

Participants

Reaction Steps

1-{[(Methyloxy)methyl]oxy}-2-{4-[(phenylmethyl)oxy]phenyl}-3-(trifluoromethyl)naphthalene (185) (0.32 g, 0.72 mmol) was treated with 4.0M HCl in dioxane at room temperature to give 0.28 g (99%) of the title compound (186) as a white solid. 1H NMR (400 MHz, CDCl3): δ 5.14 (s, 2H), 5.48 (s, 1H), 7.14 (d, J=8.6 Hz, 2H), 7.31 (d, J=8.6 Hz, 2H), 7.34-7.40 (m, 1H), 7.40-7.50 (m, 2H), 7.49 (d, J=7.3 Hz, 2H), 7.57-7.65 (m, 2H), 7.85 (s, 1H), 7.88-7.94 (m, 1H), 8.24-8.29 (m, 1H). LCMS (ESI): m/z 417 (M+Na)+, m/z 393 (M−H)−.

Provenance & Evidence