Cesium carbonate → HCID 86616665, compound

Participants

Reaction Steps

2-{4-[(Phenylmethyl)oxy]phenyl}-3-(trifluoromethyl)-1-naphthalenol (186) (0.25 g, 0.64 mmol) and 4-fluorobenzaldehyde was heated with Cs2CO3 in DMSO at 100° C. for 5 h using microwave synthesizer to give 0.23 g (71%) of the title compound (187) as a light brown viscous oil. 1H NMR (400 MHz, CDCl3): δ 5.01 (s, 2H), 6.67 (d, J=8.6 Hz, 2H), 6.83 (d, J=8.6 Hz, 2H), 7.06 (d, J=8.4 Hz, 2H), 7.30-7.44 (m, 5H), 7.57-7.68 (m, 4H), 7.88 (d, J=8.3 Hz, 1H), 8.04 (d, J=8.1 Hz, 1H), 8.25 (s, 1H), 9.82 (s, 1H). LCMS (ESI): m/z 521 (M+Na)+.

Provenance & Evidence