Sodium Hydroxide → HCID 11604240, compound

Participants

Reaction Steps

Methyl ester (189) (63 mg, 0.15 mmol) was saponified with 1 N NaOH in THF and EtOH to give 48 mg (79%) of the title compound (190) as a white solid. mp 244-245° C. 1H NMR (400 MHz, CH3OH-d4): δ 6.60 (d, J=8.8 Hz, 2H), 6.64 (d, J=8.6 Hz, 2H), 6.96 (d, J=8.4 Hz, 2H), 7.60-7.72 (m, 2H), 7.79 (d, J=9.0 Hz, 2H), 7.88 (d, J=8.1 Hz, 1H), 8.15 (d, J=7.9 Hz, 1H), 8.34 (s, 1H). LCMS (ESI): m/z 447 (M+Na)+, m/z 423 (M−H)−. Anal. Calc for C24H15F3O4.0.25H2O: C, 67.21; H, 3.64. Found: C, 67.05; H, 3.47.

Provenance & Evidence