HCID 86087169, compound → HCID 68534724, compound

Participants

Reaction Steps

2-(1-Decyn-1-yl)-N-methyl-N,4-bis(methyloxy)benzamide (192) (0.80 g, 2.41 mmol) was treated with benzylmagnesium chloride in THF to give 0.80 g (91%) of compound 193 as a yellow oil. 1H NMR (400 MHz, CDCl3): δ 0.85-0.90 (m, 3H), 1.20-1.37 (m, 8H), 1.40-1.50 (m, 2H), 1.55-1.65 (m, 2H), 2.45 (t, J=7.2 Hz, 2H), 3.83 (s, 3H), 4.45 (s, 2H), 6.83 (dd, J1=8.7 Hz, J2=2.7 Hz, 1H), 6.98 (d, J=2.8 Hz, 1H), 7.70-7.26 (m, 3H), 7.27-7.33 (m, 2H), 7.66 (d, J=8.8 Hz, 1H). LCMS (ESI): m/z 363 (M+H)+, m/z 361 (M−H)−.

Provenance & Evidence