Potassium bis(trimethylsilyl)amide → HCID 68541212, compound

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Reaction Steps

A solution of 1-[2-(1-decyn-1-yl)-4-(methyloxy)phenyl]-2-phenylethanone (192) (0.80 g, 2.21 mmol) in toluene was treated with a KHMDS solution in toluene to give 0.60 g (75%) of the title compound (193) as a light brown oil. 1H NMR (400 MHz, CDCl3): δ 0.85 (t, J=7.1 Hz, 3H), 1.10-1.30 (m, 10H), 1.35-1.50 (m, 2H), 2.46 (t, J=7.3 Hz, 2H), 3.93 (s, 3H), 5.16 (s, 1H), 7.06-7.10 (m, 2H), 7.22 (s, 1H), 7.32-7.37 (m, 2H), 7.42-7.48 (m, 1H), 7.50-7.56 (m, 2H), 8.08 (d, J=9.8 Hz, 1H). LCMS (ESI): m/z 363 (M+H)+, m/z 361 (M−H)−.

Provenance & Evidence